F
IPR044288

E3 ubiquitin-protein ligase ZNF598/Hel2

InterPro entry
Short nameZNF598/Hel2

Description

This entry includes ZNF598 from animals and Hel2 from yeasts. They are RING finger ubiquitin ligases (E3) that play a key role in the ribosome quality control (RQC)
[3, 2]
. Hel2 is involved ubiquitination and degradation of excess histones
[5, 1]
. ZNF598 is associates with eukaryotic initiation factor 4E (eIF4E) homologous protein from mammalian (m4EHP) through binding to Grb10-interacting GYF protein 2 (GIGYF2). The m4EHP-GIGYF2 complex functions as a translational repressor and is essential for normal embryonic development of mammalian
[4]
.

References

1.Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways. Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T. EMBO J 38, (2019). PMID: 30609991

2.ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ. Mol. Cell 65, 751-760.e4, (2017). View articlePMID: 28132843

3.Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Juszkiewicz S, Hegde RS. Mol. Cell 65, 743-750.e4, (2017). View articlePMID: 28065601

4.A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N. Mol. Cell. Biol. 32, 3585-93, (2012). View articlePMID: 22751931

5.Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae. Singh RK, Gonzalez M, Kabbaj MH, Gunjan A. PLoS ONE 7, e36295, (2012). View articlePMID: 22570702

GO terms

cellular component

  • None

Cross References

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