F
IPR044570

Histone-lysine N-methyltransferase Set1-like

InterPro entry
Short nameSet1-like
family relationships

Description

The COMPASS complex (complex proteins associated with Set1) is conserved in yeasts and in other eukaryotes up to humans. This entry represents Set1 and its homologues. Set1 is a methyltransferase and the catalytic component of the COMPASS that produces trimethylated histone H3 at Lys(4).

The yeast COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation
[5, 3, 6]
. In yeasts, the Set1C complex consists of Set1(2), Bre2(2), Spp1(2), Sdc1(1), Shg1(1), Swd1(1), Swd2(1), and Swd3(1)
[8, 4, 7, 9]
.

In animals, SETD1A/B are histone methyltransferases that produce mono-, di-, and trimethylated histone H3 at 'Lys-4. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation
[2, 1]
. The animal COMPASS complex is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30
[1]
.

ATXR7, the Arabidopsis homologue to Set1, is required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family
[12, 11]
. ATXR7 is also involved in the control of seed dormancy and germination
[10]
.

References

1.Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. Lee JH, Tate CM, You JS, Skalnik DG. J. Biol. Chem. 282, 13419-28, (2007). View articlePMID: 17355966

2.CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. Lee JH, Skalnik DG. J. Biol. Chem. 280, 41725-31, (2005). View articlePMID: 16253997

3.Molecular regulation of H3K4 trimethylation by Wdr82, a component of the human Set1/COMPASS. Wu M, Wang PF, Lee JS, Martin-Brown S, Florens L, Washburn M, Shilatifard A. Mol. Cell. Biol. (2008). PMID: 18838538

4.COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Miller T, Krogan NJ, Dover J, Erdjument-Bromage H, Tempst P, Johnston M, Greenblatt JF, Shilatifard A. Proc. Natl. Acad. Sci. U.S.A. 98, 12902-7, (2001). View articlePMID: 11687631

5.Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation. Vitaliano-Prunier A, Menant A, Hobeika M, Geli V, Gwizdek C, Dargemont C. Nat. Cell Biol. 10, 1365-71, (2008). View articlePMID: 18849979

6.Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Lee JS, Shukla A, Schneider J, Swanson SK, Washburn MP, Florens L, Bhaumik SR, Shilatifard A. Cell 131, 1084-96, (2007). View articlePMID: 18083099

7.High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. Roguev A, Schaft D, Shevchenko A, Aasland R, Shevchenko A, Stewart AF. J. Biol. Chem. 278, 8487-93, (2003). View articlePMID: 12488447

8.Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Corda Y, Schramke V, Longhese MP, Smokvina T, Paciotti V, Brevet V, Gilson E, Geli V. Nat. Genet. 21, 204-8, (1999). View articlePMID: 9988274

9.A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Roguev A, Shevchenko A, Schaft D, Thomas H, Stewart AF, Shevchenko A. Mol. Cell Proteomics 3, 125-32, (2004). View articlePMID: 14617822

10.Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy. Liu Y, Geyer R, van Zanten M, Carles A, Li Y, Horold A, van Nocker S, Soppe WJ. PLoS ONE 6, e22241, (2011). View articlePMID: 21799800

11.ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C. Tamada Y, Yun JY, Woo SC, Amasino RM. Plant Cell 21, 3257-69, (2009). View articlePMID: 19855050

12.SET DOMAIN GROUP25 encodes a histone methyltransferase and is involved in FLOWERING LOCUS C activation and repression of flowering. Berr A, Xu L, Gao J, Cognat V, Steinmetz A, Dong A, Shen WH. Plant Physiol. 151, 1476-85, (2009). View articlePMID: 19726574

GO terms

biological process

  • None

cellular component

  • None

Cross References

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