IPR044917
DNA-directed primase/polymerase protein
InterPro entry
Short name | PRIMPOL |
Description
PRIMPOL has both DNA polymerase and DNA/RNA primase activities. It is involved in downstream repriming of stalled forks during both nuclear and mitochondrial DNA replication. It pays an important part in DNA damage tolerance
[3]. It is predicted to possess an archaeo-eukaryotic primase and a UL52-like zinc finger domain
[4, 1]. The primase activity of PRIMPOL is essential for many functions in the nucleus. However, the role of PRIMPOL polymerase activity is still unclear, as PRIMPOL synthesizes DNA with limited processivity, rarely incorporating more than four nucleotides on an undamaged template
[2].
References
1.Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Keen BA, Jozwiakowski SK, Bailey LJ, Bianchi J, Doherty AJ. Nucleic Acids Res 42, 5830-45, (2014). PMID: 24682820
2.To skip or not to skip: choosing repriming to tolerate DNA damage. Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A. Mol Cell 81, 649-658, (2021). PMID: 33515486
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PANTHER:PTHR31399