F
IPR044917

DNA-directed primase/polymerase protein

InterPro entry
Short namePRIMPOL

Description

PRIMPOL has both DNA polymerase and DNA/RNA primase activities. It is involved in downstream repriming of stalled forks during both nuclear and mitochondrial DNA replication. It pays an important part in DNA damage tolerance
[3]
. It is predicted to possess an archaeo-eukaryotic primase and a UL52-like zinc finger domain
[4, 1]
. The primase activity of PRIMPOL is essential for many functions in the nucleus. However, the role of PRIMPOL polymerase activity is still unclear, as PRIMPOL synthesizes DNA with limited processivity, rarely incorporating more than four nucleotides on an undamaged template
[2]
.

References

1.Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Keen BA, Jozwiakowski SK, Bailey LJ, Bianchi J, Doherty AJ. Nucleic Acids Res 42, 5830-45, (2014). PMID: 24682820

2.To skip or not to skip: choosing repriming to tolerate DNA damage. Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A. Mol Cell 81, 649-658, (2021). PMID: 33515486

3.PRIMPOL ready, set, reprime! Tirman S, Cybulla E, Quinet A, Meroni A, Vindigni A. Crit Rev Biochem Mol Biol 56, 17-30, (2021). PMID: 33179522

4.Structure and mechanism of human PrimPol, a DNA polymerase with primase activity. Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Sci Adv 2, e1601317, (2016). PMID: 27819052

GO terms

Cross References

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