F
IPR045023

Acyl-[acyl-carrier-protein] hydrolase FATA/B

InterPro entry
Short nameFATA/B

Description

This family represents acyl-acyl carrier protein (ACP) thioesterases (
3.1.2.-
), enzymes from bacteria and plants that control the termination of fatty acid synthesis by hydrolyzing the acyl-ACP complexes and determines the fatty acid profiles produced by an organism
[1, 3, 2]
. These enzymes are classified as FatA and FatB. FatA thioesterases (or oleoyl-thioesterases) are highly conserved between different plant species and have high specificity for oleoyl-ACP
[1]
. Unlike FatA, FatB thioesterases are much more variable and preferentially hydrolyse acyl-ACPs with saturated fatty acyl chains; they can be classified in subfamilies depending on their substrate of preference
[4]
.

References

1.Reduced expression of FatA thioesterases in Arabidopsis affects the oil content and fatty acid composition of the seeds. Moreno-Perez AJ, Venegas-Caleron M, Vaistij FE, Salas JJ, Larson TR, Garces R, Graham IA, Martinez-Force E. Planta 235, 629-39, (2012). PMID: 22002626

2.Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. Jing F, Cantu DC, Tvaruzkova J, Chipman JP, Nikolau BJ, Yandeau-Nelson MD, Reilly PJ. BMC Biochem 12, 44, (2011). PMID: 21831316

3.Identification of active site residues implies a two-step catalytic mechanism for acyl-ACP thioesterase. Jing F, Yandeau-Nelson MD, Nikolau BJ. Biochem J 475, 3861-3873, (2018). PMID: 30409825

4.Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases. Salas JJ, Ohlrogge JB. Arch Biochem Biophys 403, 25-34, (2002). PMID: 12061798

GO terms

Cross References

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