IPR045023
Acyl-[acyl-carrier-protein] hydrolase FATA/B
InterPro entry
Short name | FATA/B |
Description
This family represents acyl-acyl carrier protein (ACP) thioesterases (
3.1.2.-), enzymes from bacteria and plants that control the termination of fatty acid synthesis by hydrolyzing the acyl-ACP complexes and determines the fatty acid profiles produced by an organism
[1, 3, 2]. These enzymes are classified as FatA and FatB. FatA thioesterases (or oleoyl-thioesterases) are highly conserved between different plant species and have high specificity for oleoyl-ACP
[1]. Unlike FatA, FatB thioesterases are much more variable and preferentially hydrolyse acyl-ACPs with saturated fatty acyl chains; they can be classified in subfamilies depending on their substrate of preference
[4].
References
1.Reduced expression of FatA thioesterases in Arabidopsis affects the oil content and fatty acid composition of the seeds. Moreno-Perez AJ, Venegas-Caleron M, Vaistij FE, Salas JJ, Larson TR, Garces R, Graham IA, Martinez-Force E. Planta 235, 629-39, (2012). PMID: 22002626
2.Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. Jing F, Cantu DC, Tvaruzkova J, Chipman JP, Nikolau BJ, Yandeau-Nelson MD, Reilly PJ. BMC Biochem 12, 44, (2011). PMID: 21831316
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PANTHER:PTHR31727
Representative structure
4gak: Crystal structure of acyl-ACP thioesterase from Spirosoma linguale