F
IPR045316

Zinc transporter Msc2-like

InterPro entry
Short nameMsc2-like
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents a group of metal transporters, including Msc2 from budding yeasts, Cis4 from fission yeasts, SLC30A5/7 (also known as ZNT7/5) from humans and MTPC2/MTP12 from Arabidopsis. They are zinc transporters involved in zinc ion homeostasis
[1, 2, 3, 4]
. ZNT5/7 in the early secretory pathway, regulate the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis
[5]
.

References

1.The yeast gene MSC2, a member of the cation diffusion facilitator family, affects the cellular distribution of zinc. Li L, Kaplan J. J Biol Chem 276, 5036-43, (2001). PMID: 11058603

2.Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeast. Fang Y, Sugiura R, Ma Y, Yada-Matsushima T, Umeno H, Kuno T. Mol Biol Cell 19, 1295-303, (2008). PMID: 18199682

3.Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. Suzuki T, Ishihara K, Migaki H, Ishihara K, Nagao M, Yamaguchi-Iwai Y, Kambe T. J Biol Chem 280, 30956-62, (2005). PMID: 15994300

4.A high molecular mass zinc transporter MTP12 forms a functional heteromeric complex with MTP5 in the Golgi in Arabidopsis thaliana. Fujiwara T, Kawachi M, Sato Y, Mori H, Kutsuna N, Hasezawa S, Maeshima M. FEBS J 282, 1965-79, (2015). PMID: 25732056

5.Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression. Wagatsuma T, Shimotsuma K, Sogo A, Sato R, Kubo N, Ueda S, Uchida Y, Kinoshita M, Kambe T. J Biol Chem 298, 102011, (2022). PMID: 35525268

GO terms

Contributing Member Database Entry
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