H
IPR046349

C1-like domain superfamily

InterPro entry
Short nameC1-like_sf
Overlapping entries
 
DC1 (IPR004146)

Description

This superfamily includes variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content. The C1 domain is the N-terminal region of conservation found in protein kinase C domains. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and zinc
[1]
. This superfamily also includes the C-terminal domain of General transcription factor IIH subunit 2 whose structure revealed homology with the regulatory domain of protein kinase C
[2]
.

References

1.The protein kinase C family. Azzi A, Boscoboinik D, Hensey C. Eur. J. Biochem. 208, 547-57, (1992). View articlePMID: 1396661

2.Structural characterization of the cysteine-rich domain of TFIIH p44 subunit. Fribourg S, Kellenberger E, Rogniaux H, Poterszman A, Van Dorsselaer A, Thierry JC, Egly JM, Moras D, Kieffer B. J. Biol. Chem. 275, 31963-71, (2000). View articlePMID: 10882739

Cross References

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