IPR046349
C1-like domain superfamily
InterPro entry
Short name | C1-like_sf |
Overlapping entries |
Description
This superfamily includes variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content. The C1 domain is the N-terminal region of conservation found in protein kinase C domains. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and zinc
[1]. This superfamily also includes the C-terminal domain of General transcription factor IIH subunit 2 whose structure revealed homology with the regulatory domain of protein kinase C
[2].
References
1.The protein kinase C family. Azzi A, Boscoboinik D, Hensey C. Eur. J. Biochem. 208, 547-57, (1992). View articlePMID: 1396661
2.Structural characterization of the cysteine-rich domain of TFIIH p44 subunit. Fribourg S, Kellenberger E, Rogniaux H, Poterszman A, Van Dorsselaer A, Thierry JC, Egly JM, Moras D, Kieffer B. J. Biol. Chem. 275, 31963-71, (2000). View articlePMID: 10882739
Cross References
Contributing Member Database Entry
- SUPERFAMILY:SSF57889
Representative structure
7lf3: C1B domain of Protein kinase C in complex with diacylglycerol-lactone AJH-836