F
IPR046432

TASOR

InterPro entry
Short nameTASOR

Description

TASOR is a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements
[6, 1, 2]
. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin
[1, 2, 4]
. The HUSH complex represses L1 retrotransposons and is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed
[3]
. TASOR is crucial in early embryonic development
[5]
, and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements.

References

1.GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Gottgens B, Dougan G, Dawson MA, Lehner PJ. Science 348, 1481-1485, (2015). View articlePMID: 26022416

2.Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ. Nat Genet 49, 1035-1044, (2017). PMID: 28581500

3.NP220 mediates silencing of unintegrated retroviral DNA. Zhu Y, Wang GZ, Cingoz O, Goff SP. Nature 564, 278-282, (2018). PMID: 30487602

4.Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Liu N, Lee CH, Swigut T, Grow E, Gu B, Bassik MC, Wysocka J. Nature 553, 228-232, (2018). PMID: 29211708

5.The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K. Sci Rep 7, 9322, (2017). PMID: 28839193

6.TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control. Douse CH, Tchasovnikarova IA, Timms RT, Protasio AV, Seczynska M, Prigozhin DM, Albecka A, Wagstaff J, Williamson JC, Freund SMV, Lehner PJ, Modis Y. Nat Commun 11, 4940, (2020). PMID: 33009411

GO terms

molecular function

  • None

cellular component

  • None
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