NSP1, globular domain, alpha/betacoronavirus
Short name | a/bCoV_NSP1_glob |
Overlapping homologous superfamilies | |
domain relationships |
Description
References
1.Structure of alphacoronavirus transmissible gastroenteritis virus nsp1 has implications for coronavirus nsp1 function and evolution. Jansson AM. J. Virol. 87, 2949-55, (2013). View articlePMID: 23269811
2.Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1. Shen Z, Ye G, Deng F, Wang G, Cui M, Fang L, Xiao S, Fu ZF, Peng G. J Virol 92, e01896-17, (2018). PMID: 29237834
3.Structural characterization of nonstructural protein 1 from SARS-CoV-2. Semper C, Watanabe N, Savchenko A. iScience 24, 101903, (2021). PMID: 33319167
4.A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence. Shen Z, Wang G, Yang Y, Shi J, Fang L, Li F, Xiao S, Fu ZF, Peng G. J Biol Chem 294, 13606-13618, (2019). PMID: 31350335
5.Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus. Almeida MS, Johnson MA, Herrmann T, Geralt M, Wuthrich K. J. Virol. 81, 3151-61, (2007). View articlePMID: 17202208
6.Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. Lokugamage KG, Narayanan K, Huang C, Makino S. J. Virol. 86, 13598-608, (2012). PMID: 23035226
7.Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression. Narayanan K, Ramirez SI, Lokugamage KG, Makino S. Virus Res. 202, 89-100, (2015). PMID: 25432065
8.SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. PLoS Pathog. 7, e1002433, (2011). PMID: 22174690
9.A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein. Kamitani W, Huang C, Narayanan K, Lokugamage KG, Makino S. Nat. Struct. Mol. Biol. 16, 1134-40, (2009). PMID: 19838190
10.Evasion of Type I Interferon by SARS-CoV-2. Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY. Cell Rep 33, 108234, (2020). PMID: 32979938
11.SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. Schubert K, Karousis ED, Jomaa A, Scaiola A, Echeverria B, Gurzeler LA, Leibundgut M, Thiel V, Muhlemann O, Ban N. Nat Struct Mol Biol 27, 959-966, (2020). PMID: 32908316
12.SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Banerjee AK, Blanco MR, Bruce EA, Honson DD, Chen LM, Chow A, Bhat P, Ollikainen N, Quinodoz SA, Loney C, Thai J, Miller ZD, Lin AE, Schmidt MM, Stewart DG, Goldfarb D, De Lorenzo G, Rihn SJ, Voorhees RM, Botten JW, Majumdar D, Guttman M. Cell 183, 1325-1339.e21, (2020). PMID: 33080218
Cross References
Contributing Member Database Entry
- PROSITE profiles:PS51962