D
IPR047256

Tyrosine-protein kinase BAZ1B, PHD finger

InterPro entry
Short nameBAZ1B_PHD
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the plant homeodomain (PHD) finger of BAZ1B
[2]
.

BAZ1B (also known as Williams-Beuren syndrome transcription factor, WSTF) is a multifunctional protein implicated in several nuclear processes, including replication, transcription, and the DNA damage response. It is a component of the WICH complex (WSTF-ISWI ATP-dependent chromatin-remodelling complex). It has intrinsic tyrosine kinase activity by means of a domain that shares no sequence homology to any known kinase fold. It has been shown to phosphorylate Tyr 142 of H2A
[1]
. It is involved in chromatin assembly, RNA polymerase I and III gene regulation, vitamin D metabolism, and DNA repair
[3]
.

References

1.WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. Nature 457, 57-62, (2009). View articlePMID: 19092802

2.Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. Pascual J, Martinez-Yamout M, Dyson HJ, Wright PE. J. Mol. Biol. 304, 723-9, (2000). View articlePMID: 11124022

3.WSTF does it all: a multifunctional protein in transcription, repair, and replication. Barnett C, Krebs JE. Biochem. Cell Biol. 89, 12-23, (2011). View articlePMID: 21326359

Cross References

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