IPR047256
Tyrosine-protein kinase BAZ1B, PHD finger
InterPro entry
Short name | BAZ1B_PHD |
Overlapping homologous superfamilies | |
domain relationships |
Description
BAZ1B (also known as Williams-Beuren syndrome transcription factor, WSTF) is a multifunctional protein implicated in several nuclear processes, including replication, transcription, and the DNA damage response. It is a component of the WICH complex (WSTF-ISWI ATP-dependent chromatin-remodelling complex). It has intrinsic tyrosine kinase activity by means of a domain that shares no sequence homology to any known kinase fold. It has been shown to phosphorylate Tyr 142 of H2A
[1]. It is involved in chromatin assembly, RNA polymerase I and III gene regulation, vitamin D metabolism, and DNA repair
[3].
References
1.WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. Nature 457, 57-62, (2009). View articlePMID: 19092802
2.Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. Pascual J, Martinez-Yamout M, Dyson HJ, Wright PE. J. Mol. Biol. 304, 723-9, (2000). View articlePMID: 11124022
3.WSTF does it all: a multifunctional protein in transcription, repair, and replication. Barnett C, Krebs JE. Biochem. Cell Biol. 89, 12-23, (2011). View articlePMID: 21326359
Cross References
ENZYME
Contributing Member Database Entry
- CDD:cd15628