D
IPR047258

QUIRKY-like, third C2 domain

InterPro entry
Short nameC2C_MCTP_PRT_plant
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the third C2 domain, referred to as C2C, from QUIRKY and related proteins. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions
[5, 6]
.

This entry includes a group of plant proteins, such as QUIRKY and FTIP1/3/4/7 from Arabidopsis
[2, 3]
. These are Multiple C2 domain and Transmembrane region Proteins (MCTPs) which are involved in Ca2 signalling at the membrane. Plant-MCTPs are composed of a variable N-terminal sequence, four C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2 but not phospholipids.

QUIRKY may contribute to plant organ organogenesis mediated by the receptor-like kinase STRUBBELIG and may play a role in Ca2-dependent signaling and membrane trafficking
[2]
. It has been shown to be required for the appropriate spatial expression of several epidermal cell fate regulators
[4]
. FTIP1 is involved in the export of FT from the phloem companion cells to the sieve elements through the plasmodesmata. It regulates flowering time under long days
[2]
. FTIP3/4 play an essential role in mediating proliferation and differentiation of shoot stem cells
[3]
. FTIP7 promotes nuclear translocation of the transcription factor OSH1 and reduces auxin levels at late stage of anther development, after meiosis of microspore mother cells. It is necessary for normal anther dehiscence and seed setting
[1]
.

References

1.OsFTIP7 determines auxin-mediated anther dehiscence in rice. Song S, Chen Y, Liu L, See YHB, Mao C, Gan Y, Yu H. Nat Plants 4, 495-504, (2018). PMID: 29915329

2.FTIP1 is an essential regulator required for florigen transport. Liu L, Liu C, Hou X, Xi W, Shen L, Tao Z, Wang Y, Yu H. PLoS Biol 10, e1001313, (2012). PMID: 22529749

3.FTIP-Dependent STM Trafficking Regulates Shoot Meristem Development in Arabidopsis. Liu L, Li C, Song S, Teo ZWN, Shen L, Wang Y, Jackson D, Yu H. Cell Rep 23, 1879-1890, (2018). PMID: 29742441

4.QUIRKY regulates root epidermal cell patterning through stabilizing SCRAMBLED to control CAPRICE movement in Arabidopsis. Song JH, Kwak SH, Nam KH, Schiefelbein J, Lee MM. Nat Commun 10, 1744, (2019). PMID: 30988311

5.C2-domains, structure and function of a universal Ca2+-binding domain. Rizo J, Sudhof TC. J. Biol. Chem. 273, 15879-82, (1998). View articlePMID: 9632630

6.The C2 domain calcium-binding motif: structural and functional diversity. Nalefski EA, Falke JJ. Protein Sci. 5, 2375-90, (1996). View articlePMID: 8976547

Further reading

7. Characterization of Multiple C2 Domain and Transmembrane Region Proteins in Arabidopsis. Liu L, Li C, Liang Z, Yu H. Plant Physiol 176, 2119-2132, (2018). PMID: 29259105

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