E3 ubiquitin-protein ligase parkin, RING finger, HC subclass
Short name | RING-HC_RBR_parkin |
domain relationships |
Description
References
1.Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation. Trempe JF, Sauve V, Grenier K, Seirafi M, Tang MY, Menade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K. Science (2013). PMID: 23661642
2.UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Wenzel DM, Lissounov A, Brzovic PS, Klevit RE. Nature 474, 105-8, (2011). View articlePMID: 21532592
3.USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria. Cunningham CN, Baughman JM, Phu L, Tea JS, Yu C, Coons M, Kirkpatrick DS, Bingol B, Corn JE. Nat Cell Biol 17, 160-9, (2015). PMID: 25621951
4.Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. Olzmann JA, Li L, Chudaev MV, Chen J, Perez FA, Palmiter RD, Chin LS. J Cell Biol 178, 1025-38, (2007). PMID: 17846173
5.Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H. EMBO J 34, 2506-21, (2015). PMID: 26254304
6.A Ubl/ubiquitin switch in the activation of Parkin. Sauve V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K. EMBO J 34, 2492-505, (2015). PMID: 26254305
7.A novel role for parkin in trauma-induced central nervous system secondary injury. Mukhida K, Kobayashi NR, Mendez I. Med Hypotheses 64, 1120-3, (2005). PMID: 15823698
8.Functional Role of Parkin against Oxidative Stress in Neural Cells. Hwang M, Lee JM, Kim Y, Geum D. Endocrinol Metab (Seoul) 29, 62-9, (2014). PMID: 24741456
9.PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. J Cell Biol 205, 143-53, (2014). PMID: 24751536
10.Mechanism of phospho-ubiquitin-induced PARKIN activation. Wauer T, Simicek M, Schubert A, Komander D. Nature 524, 370-4, (2015). PMID: 26161729
11.Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. Imai Y, Soda M, Takahashi R. J Biol Chem 275, 35661-4, (2000). PMID: 10973942
12.Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. da Costa CA, Sunyach C, Giaime E, West A, Corti O, Brice A, Safe S, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F. Nat Cell Biol 11, 1370-5, (2009). PMID: 19801972
Cross References
ENZYME
Contributing Member Database Entry
- CDD:cd16627