D
IPR047549

BICC1, first type I KH domain

InterPro entry
Short nameBICC1_KH-I_rpt1
domain relationships

Description

This entry represents the first type I KH RNA-binding domain of BICC/BICC1.

Bicaudal-C from Drosophila melanogaster (BICC) and its homologues from vertebrates BICC1, are RNA-binding proteins with translational repression function; they regulate gene expression and modulate cell proliferation and apoptosis
[4]
. BICC1 is a negative regulator of Wnt signalling
[5]
. These proteins are involved in the regulation of embryonic differentiation and play a role in the regulation of Dvl (Dishevelled) signalling, particularly in the correct cilia orientation and nodal flow generation
[2]
. In Drosophila, disruption of BICC can disturb the normal migration direction of the anterior follicle cell of oocytes
[3]
. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates
[1]
.

BICC1 contains N-terminal K homology (KH) RNA-binding vigilin-like repeats and a C-terminal SAM domain.

References

1.The polycystic kidney disease-related proteins Bicc1 and SamCystin interact. Stagner EE, Bouvrette DJ, Cheng J, Bryda EC. Biochem. Biophys. Res. Commun. 383, 16-21, (2009). View articlePMID: 19324013

2.Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow. Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB. Development 136, 3019-30, (2009). View articlePMID: 19666828

3.Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C. Saffman EE, Styhler S, Rother K, Li W, Richard S, Lasko P. Mol. Cell. Biol. 18, 4855-62, (1998). View articlePMID: 9671494

4.A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators. Park S, Blaser S, Marchal MA, Houston DW, Sheets MD. Development 143, 864-71, (2016). View articlePMID: 26811381

5.Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. Kraus MR, Clauin S, Pfister Y, Di Maio M, Ulinski T, Constam D, Bellanne-Chantelot C, Grapin-Botton A. Hum Mutat 33, 86-90, (2012). PMID: 21922595

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