Ovarian tumor domain-containing protein 1, OTU domain
Short name | OTUD1_OTU |
Overlapping homologous superfamilies | |
domain relationships |
Description
References
1.A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Makarova KS, Aravind L, Koonin EV. Trends Biochem. Sci. 25, 50-2, (2000). View articlePMID: 10664582
2.OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. Cell 154, 169-84, (2013). View articlePMID: 23827681
3.Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L. Nat Commun 8, 2116, (2017). PMID: 29235476
4.Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders. Lu D, Song J, Sun Y, Qi F, Liu L, Jin Y, McNutt MA, Yin Y. J Autoimmun 94, 156-165, (2018). PMID: 30100102
5.SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. Nat Commun 9, 2269, (2018). PMID: 29891922
6.The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein. Wu L, Lin Y, Feng J, Qi Y, Wang X, Lin Q, Shi W, Zheng E, Wang W, Hou Z, Lin H, Yu C, He Y, Xu Y, Yang H, Lin L, Li L. Cancer Cell Int 19, 222, (2019). PMID: 31467488
7.Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome. Zhang L, Liu J, Qian L, Feng Q, Wang X, Yuan Y, Zuo Y, Cheng Q, Miao Y, Guo T, Zheng X, Zheng H. PLoS Pathog 14, e1007067, (2018). PMID: 29734366
Cross References
ENZYME
Contributing Member Database Entry
- CDD:cd22747