D
IPR047854

Replication factor C, lid domain

InterPro entry
Short nameRFC_lid
Overlapping
homologous
superfamilies
 

Description

Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA superfamily and consist of a ATPase domain, a lid domain and a C-terminal domain
[3, 2, 1, 4, 5, 6]
. This entry represents the lid domain.

References

1.Evolutionary history and higher order classification of AAA+ ATPases. Iyer LM, Leipe DD, Koonin EV, Aravind L. J. Struct. Biol. 146, 11-31, (2004). View articlePMID: 15037234

2.Review: The lord of the rings: Structure and mechanism of the sliding clamp loader. Kelch BA. Biopolymers 105, 532-46, (2016). PMID: 26918303

3.The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA. Marzahn MR, Hayner JN, Finkelstein J, O'Donnell M, Bloom LB. J Biol Chem 289, 5537-48, (2014). PMID: 24436332

4.Clamp loader ATPases and the evolution of DNA replication machinery. Kelch BA, Makino DL, O'Donnell M, Kuriyan J. BMC Biol 10, 34, (2012). PMID: 22520345

5.The RFC clamp loader: structure and function. Yao NY, O'Donnell M. Subcell Biochem 62, 259-79, (2012). PMID: 22918590

6.Replication clamps and clamp loaders. Hedglin M, Kumar R, Benkovic SJ. Cold Spring Harb Perspect Biol 5, a010165, (2013). PMID: 23545418

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