IPR047854
Replication factor C, lid domain
InterPro entry
Short name | RFC_lid |
Overlapping homologous superfamilies |
Description
Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA superfamily and consist of a ATPase domain, a lid domain and a C-terminal domain
[3, 2, 1, 4, 5, 6]. This entry represents the lid domain.
References
1.Evolutionary history and higher order classification of AAA+ ATPases. Iyer LM, Leipe DD, Koonin EV, Aravind L. J. Struct. Biol. 146, 11-31, (2004). View articlePMID: 15037234
2.Review: The lord of the rings: Structure and mechanism of the sliding clamp loader. Kelch BA. Biopolymers 105, 532-46, (2016). PMID: 26918303
3.The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA. Marzahn MR, Hayner JN, Finkelstein J, O'Donnell M, Bloom LB. J Biol Chem 289, 5537-48, (2014). PMID: 24436332
4.Clamp loader ATPases and the evolution of DNA replication machinery. Kelch BA, Makino DL, O'Donnell M, Kuriyan J. BMC Biol 10, 34, (2012). PMID: 22520345
Contributing Member Database Entry
- CDD:cd18140