F
IPR047950

Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase-like

InterPro entry
Short nameBphB-like_SDR
Overlapping
homologous
superfamilies
 
family relationships

Description

Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB) is a classical SDR of particular importance for its role in the degradation of biphenyl/polychlorinated biphenyls(PCBs); PCBs are a significant source of environmental contamination
[6]
. This entry also includes Pseudomonas putida F1 cis-biphenyl-1,2-dihydrodiol-1,2-dehydrogenase (also known as cis-benzene glycol dehydrogenase, encoded by the bnzE gene), which participates in benzene metabolism. In addition, it includes Pseudomonas sp. C18 putative 1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase which participates in an upper naphthalene catabolic pathway.

SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns
[2, 3, 1, 4, 5]
.

References

1.Short-chain dehydrogenases/reductases (SDR). Jornvall H, Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D. Biochemistry 34, 6003-13, (1995). View articlePMID: 7742302

2.Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs). Persson B, Kallberg Y, Oppermann U, Jornvall H. Chem. Biol. Interact. 143-144, 271-8, (2003). View articlePMID: 12604213

3.Short-chain dehydrogenases/reductases (SDR): the 2002 update. Oppermann U, Filling C, Hult M, Shafqat N, Wu X, Lindh M, Shafqat J, Nordling E, Kallberg Y, Persson B, Jornvall H. Chem. Biol. Interact. 143-144, 247-53, (2003). View articlePMID: 12604210

4.NAD-binding domains of dehydrogenases. Lesk AM. Curr. Opin. Struct. Biol. 5, 775-83, (1995). View articlePMID: 8749365

5.Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes. Kavanagh KL, Jornvall H, Persson B, Oppermann U. Cell. Mol. Life Sci. 65, 3895-906, (2008). View articlePMID: 19011750

6.Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation. Hofer B, Eltis LD, Dowling DN, Timmis KN. Gene 130, 47-55, (1993). PMID: 8344527

Further reading

7. GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. Kleiger G, Eisenberg D. J. Mol. Biol. 323, 69-76, (2002). PMID: 12368099

8. Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes. Kallberg Y, Oppermann U, Jornvall H, Persson B. Protein Sci 11, 636-41, (2002). PMID: 11847285

9. Medium- and short-chain dehydrogenase/reductase gene and protein families : Structure-function relationships in short-chain alcohol dehydrogenases. Ladenstein R, Winberg JO, Benach J. Cell. Mol. Life Sci. 65, 3918-35, (2008). View articlePMID: 19011748

Cross References

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