IPR048300
TACO1/YebC-like, second and third domains
InterPro entry
Short name | TACO1_YebC-like_2nd/3rd_dom |
Overlapping homologous superfamilies |
Description
This entry represents a domain found in transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1
[1]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region
[2]. This entry represents the second and third domains in this protein, with one domain nested within the other.
References
1.Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmuller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA. Nat. Genet. 41, 833-7, (2009). View articlePMID: 19503089
2.The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. Liang H, Li L, Dong Z, Surette MG, Duan K. J. Bacteriol. 190, 6217-27, (2008). View articlePMID: 18641136
Contributing Member Database Entry
- Pfam:PF01709
Representative structure
1mw7: X-RAY STRUCTURE OF Y162_HELPY NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET PR6