D
IPR048300

TACO1/YebC-like, second and third domains

InterPro entry
Short nameTACO1_YebC-like_2nd/3rd_dom
Overlapping
homologous
superfamilies
 
YebC-like (IPR029072)

Description

This entry represents a domain found in transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1
[1]
. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region
[2]
. This entry represents the second and third domains in this protein, with one domain nested within the other.

References

1.Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmuller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA. Nat. Genet. 41, 833-7, (2009). View articlePMID: 19503089

2.The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. Liang H, Li L, Dong Z, Surette MG, Duan K. J. Bacteriol. 190, 6217-27, (2008). View articlePMID: 18641136

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