D
IPR048629

Inositol-tetrakisphosphate 1-kinase, preATP-grasp domain

InterPro entry
Short nameITPK1_preATP-grasp

Description

This entry represents the preATP-grasp domain of a smalll group of proteins from Entamoeba, including Inositol-tetrakisphosphate 1-kinase from Entamoeba histolytica (ITPK1)
[1]
. ITPK1 can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 which may play a regulatory function. It may also act as an isomerase
[2]
.

References

1.An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity. Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J. Mol Biochem Parasitol 108, 119-23, (2000). View articlePMID: 10802324

2.Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. Miller GJ, Wilson MP, Majerus PW, Hurley JH. Mol. Cell 18, 201-12, (2005). View articlePMID: 15837423

Cross References

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