D
IPR048735

Ca2+-activated K+ channel Slowpoke-like, C-terminal domain

InterPro entry
Short nameSlowpoke-like_C

Description

This domain is found at the cytoplasmic C terminus of the Drosophila slowpoke K channel (dSlo) (
Q03720
) and its homologues. This domain is related to the TrkA C-terminal domain (
IPR006037
).

dSlo is a potassium channel activated by both membrane depolarisation or increase in cytosolic Ca2 that mediates export of K+. Its activation dampens the excitatory events that elevate the cytosolic Ca2 concentration and/or depolarise the cell membrane
[1, 2]
.

References

1.A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Atkinson NS, Robertson GA, Ganetzky B. Science 253, 551-5, (1991). View articlePMID: 1857984

2.Calcium-activated potassium channels expressed from cloned complementary DNAs. Adelman JP, Shen KZ, Kavanaugh MP, Warren RA, Wu YN, Lagrutta A, Bond CT, North RA. Neuron 9, 209-16, (1992). View articlePMID: 1497890

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