D
IPR049128

Ribonucleases P/MRP subunit Pop8-like domain

InterPro entry
Short namePop8-like_dom

Description

This entry represents the structural domain of Pop8 from yeast, which is a component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. It is also a component of Ribonuclease MRP, which cleaves pre-rRNA sequences
[1]
. Ribonuclease P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. Ribonuclease MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the Ribonuclease P complex
[2]
. Pop8 interacts with Pop5 and Rpp1 to form the Pop5-Pop8-(Rpp1)2 heterotetramer, which is part of the arm module of the protein hook
[2]
. This domain can be found in multidomain protein sequences from fungi.

References

1.Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Chamberlain JR, Lee Y, Lane WS, Engelke DR. Genes Dev. 12, 1678-90, (1998). PMID: 9620854

2.Structural insight into precursor tRNA processing by yeast ribonuclease P. Lan P, Tan M, Zhang Y, Niu S, Chen J, Shi S, Qiu S, Wang X, Peng X, Cai G, Cheng H, Wu J, Li G, Lei M. Science 362, (2018). PMID: 30262633

Cross References

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