D
IPR049323

E3 ubiquitin-protein ligase CARP1, FYVE/PHD zinc finger

InterPro entry
Short nameCARP1_FYVE
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the FYVE/PHD zinc finger form E3 ubiquitin-protein ligase RNF34, also known as Caspase regulator 1 (CARP1)
[3]
. This domain is also found in similar proteins from vertebrates.

CARP1 ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis
[1]
. It negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation
[2]
.

References

1.Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. McDonald ER 3rd, El-Deiry WS. Proc Natl Acad Sci U S A 101, 6170-5, (2004). PMID: 15069192

2.CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. Yang W, Rozan LM, McDonald ER 3rd, Navaraj A, Liu JJ, Matthew EM, Wang W, Dicker DT, El-Deiry WS. J Biol Chem 282, 3273-81, (2007). PMID: 17121812

3.Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2. Tibbetts MD, Shiozaki EN, Gu L, McDonald ER 3rd, El-Deiry WS, Shi Y. Structure 12, 2257-63, (2004). View articlePMID: 15576038

Further reading

4. Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. Sasaki S, Nakamura T, Arakawa H, Mori M, Watanabe T, Nagawa H, Croce CM. Oncogene 21, 5024-30, (2002). PMID: 12118383

5. Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H. Mol Cancer Ther 4, 743-50, (2005). PMID: 15897238

6. RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism. Wei P, Pan D, Mao C, Wang YX. Mol Cell Biol 32, 266-75, (2012). PMID: 22064484

7. Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H. Oncogene 25, 3160-9, (2006). PMID: 16407826

8. High hRFI expression correlates with resistance to fluoropyrimidines in human colon cancer cell lines and in xenografts. Sasaki S, Watanabe T, Kobunai T, Konishi T, Kitayama J, Nagawa H. J Exp Clin Cancer Res 24, 397-403, (2005). PMID: 16270526

9. Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H. Anticancer Res 25, 2737-41, (2005). PMID: 16080519

10. Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence. Sasaki S, Watanabe T, Konishi T, Kitayama J, Nagawa H. J Exp Clin Cancer Res 23, 507-12, (2004). PMID: 15595643

11. Diffuse expression of hRFI is correlated with blood vessel invasion in gastric carcinoma. Sasaki S, Kitayama J, Watanabe T, Konishi T, Nagawa H. Jpn J Clin Oncol 34, 584-7, (2004). PMID: 15591455

12. CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. Yang W, Dicker DT, Chen J, El-Deiry WS. Cell Cycle 7, 670-82, (2008). PMID: 18382127

Cross References

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