D
IPR049560

SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core

InterPro entry
Short nameMeTrfase_RsmB-F_NOP2_cat
Overlapping
homologous
superfamilies
 

Description

The catalytic domain of ribosomal RNA cysteine methyltransferases is highly conserved in archaeal, bacterial and eukaryotic proteins
[4]
. It is located at the C-terminal end in ribosomal RNA methyltransferase B (RsmB, Sun, Fmu) and Nop2 and towards the N-terminal in RsmF. Escherichia coli RsmB methylates cytosine C967 in 16S rRNA
[4]
. RsmF is a multi-site-specific methyltransferase
[2]
. Nop2 methylates cytosine C2870 in the 25S rRNA of S. cerevisiae
[3]
and is critical for 60S biogenesis
[1]
.

References

1.Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. Hong B, Brockenbrough JS, Wu P, Aris JP. Mol. Cell. Biol. 17, 378-88, (1997). View articlePMID: 8972218

2.Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Demirci H, Larsen LH, Hansen T, Rasmussen A, Cadambi A, Gregory ST, Kirpekar F, Jogl G. RNA 16, 1584-96, (2010). View articlePMID: 20558545

3.Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Sharma S, Yang J, Watzinger P, Kotter P, Entian KD. Nucleic Acids Res. 41, 9062-76, (2013). View articlePMID: 23913415

4.Structure of an archaeal homologue of the bacterial Fmu/RsmB/RrmB rRNA cytosine 5-methyltransferase. Hikida Y, Kuratani M, Bessho Y, Sekine SI, Yokoyama S. Acta Crystallogr. D Biol. Crystallogr. 66, 1301-7, (2010). View articlePMID: 21123870

Further reading

5. Crystal structure of human p120 homologue protein PH1374 from Pyrococcus horikoshii. Ishikawa I, Sakai N, Tamura T, Yao M, Watanabe N, Tanaka I. Proteins 54, 814-6, (2004). View articlePMID: 14997580

Cross References

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