IPR050067
Isopropylmalate dehydratase and related enzymes AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | IPM_dehydratase_rel_enz AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The protein family is involved in the isomerization of specific tricarboxylic acids, playing a crucial role in various biosynthetic pathways. Members of this family catalyze the reversible isomerization between 2-isopropylmalate and 3-isopropylmalate through the intermediate formation of 2-isopropylmaleate. This reaction is a key step in the biosynthesis of leucine, an essential amino acid. Some family members also exhibit broad substrate specificity, catalyzing reactions involving cis-unsaturated tricarboxylic acids, including the dehydration of (R)-homocitrate to cis-homoaconitate and its hydration to homoisocitrate, which are part of the biosynthesis pathway of coenzyme B. The family includes enzymes like homoaconitase, which are involved in the alpha-aminoadipate pathway for lysine biosynthesis. The enzymes are characterized by their membership in the aconitase/IPM isomerase family and are found across a wide range of organisms, including bacteria, archaea, and eukaryotes.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR43822
Representative structure
4kp1: Crystal structure of IPM isomerase large subunit from methanococcus jannaschii (MJ0499)