IPR050082
Ribosomal RNA large subunit methyltransferase RlmE AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | RNA_methyltr_RlmE AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The RNA methyltransferase RlmE family consists of enzymes that catalyze the methylation of the 2'-O position of the ribose in specific uridine residues within ribosomal RNA (rRNA). This methylation occurs at position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit, which is a universally conserved modification in the peptidyl transferase domain of the large subunit rRNA. The modification is critical for the proper assembly and function of the ribosome, which is essential for protein synthesis. Members of this family are S-adenosyl-L-methionine (SAM)-dependent methyltransferases and share a common SAM-binding motif. They are found across a wide range of organisms, including bacteria, archaea, and eukaryotes. The methylation reaction they catalyze plays a role in the accuracy and efficiency of protein synthesis, and thus, these enzymes are vital for maintaining the fidelity of genetic translation.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR10920
Representative structure
1ej0: FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE, MERCURY DERIVATIVE