F
IPR050082

Ribosomal RNA large subunit methyltransferase RlmE
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameRNA_methyltr_RlmE
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The RNA methyltransferase RlmE family consists of enzymes that catalyze the methylation of the 2'-O position of the ribose in specific uridine residues within ribosomal RNA (rRNA). This methylation occurs at position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit, which is a universally conserved modification in the peptidyl transferase domain of the large subunit rRNA. The modification is critical for the proper assembly and function of the ribosome, which is essential for protein synthesis. Members of this family are S-adenosyl-L-methionine (SAM)-dependent methyltransferases and share a common SAM-binding motif. They are found across a wide range of organisms, including bacteria, archaea, and eukaryotes. The methylation reaction they catalyze plays a role in the accuracy and efficiency of protein synthesis, and thus, these enzymes are vital for maintaining the fidelity of genetic translation.

Cross References

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.