IPR050103
Class-III Pyridoxal-phosphate-dependent Aminotransferase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Class-III_PLP-dep_AT AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The protein family is involved in amino acid metabolism, specifically in the transamination reactions that are crucial for the synthesis and degradation of various amino acids. Members of the family function as aminotransferases, enzymes that catalyze the transfer of an amino group from a donor molecule to an acceptor. Key reactions include the conversion of putrescine to GABA via 4-aminobutanal, the interconversion of ornithine and glutamate semialdehyde, and the transamination of N(2)-succinylornithine and alpha-ketoglutarate. Some members also participate in the arginine and lysine biosynthetic pathways, acting on substrates such as acetylornithine and succinyldiaminopimelate. The family is characterized by the presence of pyridoxal phosphate as a cofactor, which is typical for class-III pyridoxal-phosphate-dependent aminotransferases.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR11986
Representative structure
2eh6: Crystal structure of acetylornithine aminotransferase from Aquifex aeolicus VF5