F
IPR050169

Krueppel C2H2-type zinc-finger
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameKrueppel_C2H2_ZnF
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The Krueppel C2H2-type zinc-finger protein family is characterized by a conserved zinc-finger domain that mediates DNA binding and is involved in transcriptional regulation. Members of this family function predominantly as transcriptional repressors or activators, influencing various biological processes including development, differentiation, apoptosis, and metabolism. Some proteins within this family are known to interact with chromatin-modifying proteins, such as SETDB1 and TRIM28/KAP1, to establish repressive chromatin states. Others are involved in maintaining genomic imprints through DNA methylation. The family also includes proteins that regulate lipid metabolism, neuron death, and retrotransposon repression in embryonic stem cells. The diversity of functions reflects the broad role of Krueppel C2H2-type zinc-finger proteins in gene expression and cellular homeostasis.
Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.