IPR050169
Krueppel C2H2-type zinc-finger AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Krueppel_C2H2_ZnF AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The Krueppel C2H2-type zinc-finger protein family is characterized by a conserved zinc-finger domain that mediates DNA binding and is involved in transcriptional regulation. Members of this family function predominantly as transcriptional repressors or activators, influencing various biological processes including development, differentiation, apoptosis, and metabolism. Some proteins within this family are known to interact with chromatin-modifying proteins, such as SETDB1 and TRIM28/KAP1, to establish repressive chromatin states. Others are involved in maintaining genomic imprints through DNA methylation. The family also includes proteins that regulate lipid metabolism, neuron death, and retrotransposon repression in embryonic stem cells. The diversity of functions reflects the broad role of Krueppel C2H2-type zinc-finger proteins in gene expression and cellular homeostasis.
Contributing Member Database Entry
- PANTHER:PTHR23232