F
IPR050185

Ubiquitin carboxyl-terminal hydrolase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameUb_carboxyl-term_hydrolase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The ubiquitin carboxyl-terminal hydrolase family, also known as deubiquitinating enzymes (DUBs), plays a crucial role in various cellular processes by cleaving ubiquitin from ubiquitinated proteins, thus regulating protein turnover and preventing degradation. Members of this family are involved in cell cycle regulation, DNA repair, transcriptional regulation, autophagy, and signal transduction. They exhibit specificity for different ubiquitin linkages and substrates, including histones, signaling receptors, and structural proteins, thereby influencing pathways such as NF-kappa-B activation, TGF-beta receptor signaling, and the spindle assembly checkpoint. Their activities contribute to the maintenance of protein homeostasis, genomic stability, and cellular response to stress and damage.

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.