IPR050185
Ubiquitin carboxyl-terminal hydrolase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Ub_carboxyl-term_hydrolase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The ubiquitin carboxyl-terminal hydrolase family, also known as deubiquitinating enzymes (DUBs), plays a crucial role in various cellular processes by cleaving ubiquitin from ubiquitinated proteins, thus regulating protein turnover and preventing degradation. Members of this family are involved in cell cycle regulation, DNA repair, transcriptional regulation, autophagy, and signal transduction. They exhibit specificity for different ubiquitin linkages and substrates, including histones, signaling receptors, and structural proteins, thereby influencing pathways such as NF-kappa-B activation, TGF-beta receptor signaling, and the spindle assembly checkpoint. Their activities contribute to the maintenance of protein homeostasis, genomic stability, and cellular response to stress and damage.
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR21646
Representative structure
3nhe: High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin