IPR050235
Casein Kinase 1 Ser/Thr Protein Kinase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | CK1_Ser-Thr_kinase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The Casein Kinase 1 (CK1) family is a group of serine/threonine-protein kinases that share a preference for acidic proteins such as caseins as substrates. Members of this family are involved in a wide range of cellular processes, including Wnt signaling, circadian rhythms, DNA repair, cell cycle regulation, and vesicular trafficking. They are known to phosphorylate a large number of proteins, influencing various signaling pathways and cellular functions. Some isoforms play key roles in the regulation of the circadian clock by determining the period length through phosphorylation of PER1 and PER2, controlling their nuclear transport and degradation. Others are involved in ciliogenesis, spermatogenesis, and responses to DNA damage. The family also includes pseudokinases that participate in viral DNA replication repression and regulation of host defense mechanisms.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR11909
Representative structure
8izc: Human CK1 Delta Kinase structure bound to Inhibitor