IPR050238
DNA Replication and Repair Clamp Loader Complex AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | DNA_Rep/Repair_Clamp_Loader AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
This family of proteins is involved in DNA replication and repair processes. Members function as part of larger protein complexes that are essential for the elongation of primed DNA templates by DNA polymerases, particularly polymerase delta and epsilon. They play a role in loading sliding clamps, such as PCNA, onto DNA, which is a critical step in DNA replication to ensure processivity of the polymerase enzymes. Some family members also possess ATPase activity and are involved in cellular processes like chromatin assembly and remodeling, as well as in the regulation of cell proliferation and the establishment of sister chromatid cohesion during DNA replication. Additionally, certain proteins within this family act as key regulators of cellular structures, such as trichome branching in plants, through pathways independent of DNA replication.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR11669