IPR050246
Class II Fructose-bisphosphate Aldolase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Class_II_FBP_aldolase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The class II fructose-bisphosphate aldolase family is involved in key metabolic processes, such as glycolysis and gluconeogenesis, by catalyzing the reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to form fructose 1,6-bisphosphate. Some members also participate in the catabolism of galactitol and the metabolism of tagatose 1,6-bisphosphate, as part of the tagatose-1,6-bisphosphate aldolase complex, which requires a GatZ subunit for full activity and stability. Additionally, a subfamily within this group is responsible for producing dihydroxyacetone phosphate and malonic semialdehyde from 6-phospho-5-dehydro-2-deoxy-D-gluconate. The family includes various subunits like GatY and KbaY, indicating a diversity of functions and substrate specificities within the broader context of carbohydrate metabolism.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR30304
Representative structure
7ncc: Crystal structure of fructose-bisphosphate aldolase FBAP from Bacillus methanolicus