IPR050259
Short-chain dehydrogenases/reductases AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | SDR AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The Short-chain dehydrogenases/reductases (SDR) family encompasses enzymes that catalyze NAD(P)(H)-dependent redox reactions on a variety of substrates, including fatty acids, steroids, and aromatic compounds. Members of the SDR family are involved in key biosynthetic pathways, such as fatty acid elongation, where they reduce beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, playing a crucial role in fatty acid biosynthesis. Other functions include the metabolism of bile acids, reduction of acetoacetyl-CoA in polyhydroxybutyrate biosynthesis, and modification of Nod factor fatty acyl chains. Some SDR enzymes are involved in antibiotic biosynthesis, such as novobiocin, or in the degradation of environmental pollutants. The family is characterized by a conserved catalytic motif and typically exhibits a Rossmann fold for binding the NAD(P) cofactor.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR42879
Representative structure
8y7r: Crystal structure of a novel ketoreductase from Sphingobacterium siyangense SY1