IPR050284
Histone deacetylase and polyamine deacetylase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | HDAC_PDAC AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
This family of proteins is involved in the regulation of gene expression through the deacetylation of lysine residues on the N-terminal part of core histones, leading to epigenetic repression. Members of this family are also capable of deacetylating non-histone proteins, influencing various cellular processes such as cell cycle progression, developmental events, and transcriptional regulation. Some proteins within this family have additional enzymatic activities, including the deacetylation of polyamines and other acyl groups from lysine residues. They are implicated in diverse biological functions, including muscle maturation, circadian rhythm regulation, autophagy, and DNA mismatch repair. These proteins form large multiprotein complexes and are often regulated by various inhibitors and activators.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR10625
Representative structure
5iwg: HDAC2 WITH LIGAND BRD4884