IPR050429
Phosphotransferase System Glucose-Specific EIICBA AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | PTS_Glucose_EIICBA AI |
Description
AI-generatedUnreviewed
The Phosphotransferase System (PTS) Glucose-Specific EIICBA Family is involved in the active transport and phosphorylation of sugars across the cell membrane, primarily glucose, but also glucosamine, N-acetylglucosamine, and various alpha- and beta-glucosides. The system operates via a phosphoenolpyruvate-dependent mechanism, where the EIIA domain receives a phosphoryl group from phospho-HPr and transfers it to the EIIB domain. The EIIB domain, in turn, phosphorylates the sugar substrate during its translocation by the EIIC domain, which forms the translocation channel and contains the substrate-binding site. The phosphorylation of sugars is a critical step in their metabolism, and the PTS plays a significant role in regulating sugar uptake based on cellular needs and environmental availability.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR30009
Representative structure
3bp3: Crystal structure of EIIB