F
IPR050429

Phosphotransferase System Glucose-Specific EIICBA
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short namePTS_Glucose_EIICBA
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Description

AI-generatedUnreviewed
The Phosphotransferase System (PTS) Glucose-Specific EIICBA Family is involved in the active transport and phosphorylation of sugars across the cell membrane, primarily glucose, but also glucosamine, N-acetylglucosamine, and various alpha- and beta-glucosides. The system operates via a phosphoenolpyruvate-dependent mechanism, where the EIIA domain receives a phosphoryl group from phospho-HPr and transfers it to the EIIB domain. The EIIB domain, in turn, phosphorylates the sugar substrate during its translocation by the EIIC domain, which forms the translocation channel and contains the substrate-binding site. The phosphorylation of sugars is a critical step in their metabolism, and the PTS plays a significant role in regulating sugar uptake based on cellular needs and environmental availability.

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