F
IPR050482

Sensor Histidine Kinase Two-Component System
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameSensor_HK_TwoCompSys
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The Sensor Histidine Kinase family comprises proteins that function as part of two-component regulatory systems, typically involved in environmental signal detection and response. These kinases autophosphorylate a conserved histidine residue in response to specific stimuli such as oxygen levels, nitrate/nitrite presence, or cell wall stress. The phosphoryl group is then transferred to a conserved aspartate residue on a response regulator, which modulates gene expression to adapt to changing conditions. Functions include regulation of genetic competence, sporulation, nitrate/nitrite reduction, biofilm formation, antibiotic response, and methanol utilization. Some members also exhibit phosphatase activity, reversing the phosphorylation state of the response regulator to modulate the signaling pathway.

Cross References

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