IPR050482
Sensor Histidine Kinase Two-Component System AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Sensor_HK_TwoCompSys AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The Sensor Histidine Kinase family comprises proteins that function as part of two-component regulatory systems, typically involved in environmental signal detection and response. These kinases autophosphorylate a conserved histidine residue in response to specific stimuli such as oxygen levels, nitrate/nitrite presence, or cell wall stress. The phosphoryl group is then transferred to a conserved aspartate residue on a response regulator, which modulates gene expression to adapt to changing conditions. Functions include regulation of genetic competence, sporulation, nitrate/nitrite reduction, biofilm formation, antibiotic response, and methanol utilization. Some members also exhibit phosphatase activity, reversing the phosphorylation state of the response regulator to modulate the signaling pathway.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR24421
Representative structure
3zxq: CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST