IPR050499
Phosphoenolpyruvate-dependent sugar PTS enzyme AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | PEP-utilizing_PTS_enzyme AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The PEP-utilizing enzyme family encompasses proteins that are key components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active-transport system. Members of this family are involved in the phosphorylation and translocation of sugar substrates across the cell membrane. The general (non sugar-specific) component, known as Enzyme I, transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). The proteins in this family are characterized by a domain architecture that includes an N-terminal domain with the HPr binding site, a central domain harboring the pyrophosphate/phosphate carrier histidine, and a C-terminal domain that binds pyruvate. Some members also participate in the transport of specific sugars like fructose, and may have additional domains for signal perception or multifunctional roles.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR46244