F
IPR050499

Phosphoenolpyruvate-dependent sugar PTS enzyme
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short namePEP-utilizing_PTS_enzyme
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The PEP-utilizing enzyme family encompasses proteins that are key components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active-transport system. Members of this family are involved in the phosphorylation and translocation of sugar substrates across the cell membrane. The general (non sugar-specific) component, known as Enzyme I, transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). The proteins in this family are characterized by a domain architecture that includes an N-terminal domain with the HPr binding site, a central domain harboring the pyrophosphate/phosphate carrier histidine, and a C-terminal domain that binds pyruvate. Some members also participate in the transport of specific sugars like fructose, and may have additional domains for signal perception or multifunctional roles.

Cross References

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