F
IPR050577

MAPR/Neuferricin/Neudesin-like

InterPro entry
Short nameMAPR/NEUFC/NENF-like
Overlapping
homologous
superfamilies
 

Description

This entry includes Membrane-associated progesterone receptor components (MAPR) such as PGRC1/2, Neuferricin, Neudesin and related proteins, which are involved in a variety of cellular functions related to heme-binding, lipid homeostasis, and membrane dynamics
[2, 4]
. PGRC2 also plays a role in adipocyte function and systemic glucose homeostasis
[1]
. Members of this entry, despite lacking conserved iron-binding His residues in their heme-binding domains, are capable of binding heme and are implicated in processes such as neuronal differentiation in the case of neuferricin and neudesin
[7, 6]
, progesterone binding, heme homeostasis, and regulation of cytochrome P450 enzymes
[2, 4, 3]
. They also act as intracellular heme chaperones and are involved in the maintenance of reproductive lifespan and systemic glucose homeostasis. Cytochrome P450 regulator dap1 from S. pombe, the orthologue of PGRC1/2, is required for sterol biosynthesis. It functions as a positive regulator of cytochrome P450 enzymes erg5 and erg11, a function that requires bound heme
[5]
.

References

1.Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF. Cell 168, 527-541.e29, (2017). View articlePMID: 28111073

2.Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450. Ryu CS, Klein K, Zanger UM. Front Pharmacol 8, 159, (2017). View articlePMID: 28396637

3.A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Piel RB 3rd, Shiferaw MT, Vashisht AA, Marcero JR, Praissman JL, Phillips JD, Wohlschlegel JA, Medlock AE. Biochemistry 55, 5204-17, (2016). View articlePMID: 27599036

4.Spectroscopic and mutagenesis studies of human PGRMC1. Kaluka D, Batabyal D, Chiang BY, Poulos TL, Yeh SR. Biochemistry 54, 1638-47, (2015). View articlePMID: 25675345

5.Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ. Cell Metab 5, 143-9, (2007). PMID: 17276356

6.Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis. Kimura I, Nakayama Y, Konishi M, Kobayashi T, Mori M, Ito M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M. J Neurochem 112, 1156-67, (2010). View articlePMID: 19968755

7.Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A, Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J, Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G, Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki Y, Foster LJ, Bader GD, Cayabyab FS, Babu M. iScience 19, 1114-1132, (2019). PMID: 31536960

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