IPR050639
Site-specific recombinase resolvase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | SSR_resolvase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The protein family includes site-specific recombinases known as resolvases, which perform crucial roles in DNA manipulation processes such as inversion and resolution of cointegrated replicons. These proteins are involved in the inversion of specific DNA segments, regulating gene expression and host specificity of viruses by altering the orientation of DNA fragments. They also catalyze the resolution of cointegrated replicons during transposition events, ensuring the proper segregation of genetic elements. The family's members share a common mechanism of action, introducing nicks into DNA, forming covalent intermediates, and executing strand exchange through a series of coordinated cleavage and religation steps. Their functions are vital for viral lifecycle, plasmid stability, and bacterial adaptability through phase variation and horizontal gene transfer.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR30461
Representative structure
3pkz: Structural basis for catalytic activation of a serine recombinase