F
IPR050664

Octanoyltransferase LipM/LipL
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameOctanoyltrans_LipM/LipL
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The octanoyltransferase LipM/LipL family includes enzymes that play a crucial role in the post-translational modification of lipoate-dependent enzymes. Members of the family catalyze the transfer of octanoic acid from octanoyl-acyl-carrier-protein to the lipoyl domain of GcvH, which is an intermediate step in protein lipoylation. Additionally, some family members are involved in the transamidation of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. This process is essential for the activation of lipoate-dependent enzymes, which are involved in critical metabolic pathways such as the citric acid cycle and glycine cleavage system. The family is characterized by the presence of octanoyltransferase activity and does not display lipoate protein ligase activity, despite some sequence similarities to LplA.

Cross References

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