F
IPR050677

Actinoporin Pore-Forming Toxin
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameActinoporin_PFT
AI
Overlapping
homologous
superfamilies
 
Cytolysin/lectin (IPR015926)

Description

AI-generatedUnreviewed
The actinoporin family comprises pore-forming toxins that target cell membranes, forming cation-selective hydrophilic pores around 1 nm in diameter, leading to cytolysis. These proteins share a domain architecture with a long N-terminal alpha-helix and a beta-sheet rich core. The pore formation process is multi-step, beginning with membrane binding via recognition of sphingomyelin, followed by oligomerization of monomers. Actinoporins are known for their hemolytic activity, and in some cases, they can cause cardiac stimulation, platelet aggregation, and cytotoxic effects. They are found in various organisms, including sea anemones, Hydra, and some plants, and are involved in defense and predation.
Contributing Member Database Entry
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