IPR050677
Actinoporin Pore-Forming Toxin AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Actinoporin_PFT AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The actinoporin family comprises pore-forming toxins that target cell membranes, forming cation-selective hydrophilic pores around 1 nm in diameter, leading to cytolysis. These proteins share a domain architecture with a long N-terminal alpha-helix and a beta-sheet rich core. The pore formation process is multi-step, beginning with membrane binding via recognition of sphingomyelin, followed by oligomerization of monomers. Actinoporins are known for their hemolytic activity, and in some cases, they can cause cardiac stimulation, platelet aggregation, and cytotoxic effects. They are found in various organisms, including sea anemones, Hydra, and some plants, and are involved in defense and predation.
Contributing Member Database Entry
- PANTHER:PTHR40388
Representative structure
1iaz: EQUINATOXIN II