IPR050703
Flavin Monoamine Oxidase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Flavin_MAO AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The flavin monoamine oxidase family is involved in the oxidative deamination of primary and secondary amines, including neurotransmitters and various xenobiotic substances. Members of this family play crucial roles in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. They catalyze reactions that typically result in the reduction of oxygen to hydrogen peroxide. Some family members have substrate specificity, such as preferentially oxidizing serotonin or degrading benzylamine and phenylethylamine. Others are involved in the degradation of nicotine or the biosynthesis of antibiotic compounds. The activity of these enzymes is regulated by various inhibitors and may involve metal cofactors alongside FAD. The family includes both well-characterized enzymes such as human MAO-A and MAO-B, as well as putative and uncharacterized proteins with predicted deaminase activity.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR43563
Representative structure
6lql: Complex structure of CHAO with product from Erythrobacteraceae bacterium