F
IPR050704

Peptidase C85-like

InterPro entry
Short namePeptidase_C85-like
Overlapping
homologous
superfamilies
 

Description

This entry represents human Deubiquitinase OTUD6B, OTU domain-containing protein 5 (OTUD5) and other C85 peptidases that contain the OTU domain (
IPR003323
). OTUD6B may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1
[4, 5]
. functions as a negative regulator of the innate immune system
[2, 3, 1, 6]
. This family also includes some viral sequences such as Putative ubiquitin thioesterase 232R from Invertebrate iridescent virus 3.

References

1.OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. Cell 154, 169-84, (2013). View articlePMID: 23827681

2.DUBA: a deubiquitinase that regulates type I interferon production. Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. Science 318, 1628-32, (2007). View articlePMID: 17991829

3.Phosphorylation-dependent activity of the deubiquitinase DUBA. Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG. Nat. Struct. Mol. Biol. 19, 171-5, (2012). View articlePMID: 22245969

4.Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. Xu Z, Zheng Y, Zhu Y, Kong X, Hu L. PLoS One 6, e14514, (2011). PMID: 21267069

5.Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Sobol A, Askonas C, Alani S, Weber MJ, Ananthanarayanan V, Osipo C, Bocchetta M. Mol Cancer Res 15, 117-127, (2017). PMID: 27864334

6.Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation. Beck DB, Basar MA, Asmar AJ, Thompson JJ, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Baranano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E; Undiagnosed Diseases Network, Matsumoto N, Inazawa J, Walkiewicz M, Ounap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A. Sci Adv 7, eabe2116, (2021). View articlePMID: 33523931

Cross References

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