IPR050776
Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Ank_Repeat/CDKN_Inhibitor AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The protein family includes ankyrin repeat domain-containing proteins and cyclin-dependent kinase inhibitors. Ankyrin repeat proteins may play roles in cell division and other regulatory functions, while cyclin-dependent kinase inhibitors are involved in cell cycle regulation by interacting with CDK4 and CDK6, inhibiting cell growth and proliferation. Some family members are involved in endosomal mRNA transport, chitinase secretion, and phosphoprotein substrate recognition. Others may act as substrate-recognition components of E3 ubiquitin-protein ligase complexes, mediating ubiquitination and proteasomal degradation of target proteins.
Contributing Member Database Entry
- PANTHER:PTHR24201
Representative structure
1bd8: STRUCTURE OF CDK INHIBITOR P19INK4D