IPR050781
Pre-mRNA-splicing factor CWC22 AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | CWC22_splicing_factor AI |
Description
AI-generatedUnreviewed
The CWC22 family is involved in pre-mRNA splicing and exon-junction complex (EJC) assembly. Members of this family are essential components of the spliceosome, participating in the splicing of both major and U12-type introns. They play a critical role in the regulation of mRNA splicing, influencing the expression of specific splice forms related to sexual differentiation in some species. Additionally, CWC22 proteins prevent EIF4A3 from non-specifically binding RNA, guiding it to the splicing machinery to facilitate EJC assembly on mature mRNAs. This function is crucial for nonsense-mediated mRNA decay, a surveillance pathway that degrades mRNAs with premature stop codons. In some organisms, CWC22 family members are also implicated in early embryogenesis, tissue differentiation, and other cellular processes such as nucleolar targeting of specific proteins and osmoregulatory glycerol response.
Contributing Member Database Entry
- PANTHER:PTHR18034
Representative structure
4c9b: Crystal structure of eIF4AIII-CWC22 complex