IPR050852
Queuine tRNA-ribosyltransferase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Queuine_tRNA-ribosyltrfase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The Queuine tRNA-ribosyltransferase family is involved in the modification of tRNA molecules. Specifically, the QTRT2 subfamily members act as non-catalytic subunits in the queuine tRNA-ribosyltransferase (TGT) complex. This complex is responsible for the base-exchange of a guanine residue with queuine at the anticodon wobble position 34 in tRNAs that recognize codons starting with guanine (GU(N) anticodons). The tRNAs targeted include those for aspartic acid, asparagine, histidine, and tyrosine. The result of this modification is the formation of the hypermodified nucleoside queuosine, which is essential for accurate and efficient protein synthesis. Queuosine is known for its role in the translational regulation and maintenance of the stability and structure of tRNA.
Contributing Member Database Entry
- PANTHER:PTHR46064
Representative structure
7b2i: Heterodimeric tRNA-Guanine Transglycosylase from mouse