F
IPR050855

Metallo-beta-lactamase type 2-like
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameNDM-1-like
AI
Overlapping
homologous
superfamilies
 
family relationships

Description

AI-generatedReviewed and updated
This entry represents Metallo-beta-lactamase type 2 from Klebsiella pneumoniae (NDM-1) and similar enzymes that share a common fold and metal-binding motif but can have different functions. NDM-1 confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring
[4, 1]
, thereby conferring resistance. Some family members exhibit acyl-CoA thioesterase activity, catalysing the hydrolysis of acyl-CoAs to free fatty acids and CoASH, which may regulate intracellular levels of these molecules
[2]
. Others are involved in the degradation of specific compounds, such as 2,4-dinitroanisole
[3]
, or play roles in the biosynthesis of signalling molecules important for biofilm formation and virulence. The family also includes uncharacterised proteins that may have metallo-hydrolase activity.

References

1.Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Zhang H, Ma G, Zhu Y, Zeng L, Ahmad A, Wang C, Pang B, Fang H, Zhao L, Hao Q. Antimicrob Agents Chemother 62, e01579-18, (2018). View articlePMID: 30150473

2.Metallo-β-lactamase domain-containing protein 2 is S-palmitoylated and exhibits acyl-CoA hydrolase activity. Malgapo MIP, Safadi JM, Linder ME. J Biol Chem 296, 100106, (2021). View articlePMID: 33219126

3.Aerobic biodegradation of 2,4-Dinitroanisole by Nocardioides sp. strain JS1661. Fida TT, Palamuru S, Pandey G, Spain JC. Appl Environ Microbiol 80, 7725-31, (2014). View articlePMID: 25281383

4.Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR. Antimicrob Agents Chemother 53, 5046-54, (2009). PMID: 19770275

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.