F
IPR050891

TatD-type Metallo-dependent Hydrolase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameTatD-type_Hydrolase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
This family of proteins includes enzymes with endonuclease and exonuclease activities, capable of incising double-stranded DNA and excising DNA from the 3'-to 5'-end. Members of this family preferentially act on single-stranded DNA and RNA substrates. They are implicated in DNA damage repair, particularly in response to oxidative stress. Additionally, some family members are involved in the decatenation of kinetoplast DNA, which is essential for chromosomal segregation and cell cycle progression, especially in eye development. The proteins belong to the metallo-dependent hydrolases superfamily and share a common TatD-type hydrolase domain.

Cross References

Contributing Member Database Entry
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