IPR050891
TatD-type Metallo-dependent Hydrolase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | TatD-type_Hydrolase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
This family of proteins includes enzymes with endonuclease and exonuclease activities, capable of incising double-stranded DNA and excising DNA from the 3'-to 5'-end. Members of this family preferentially act on single-stranded DNA and RNA substrates. They are implicated in DNA damage repair, particularly in response to oxidative stress. Additionally, some family members are involved in the decatenation of kinetoplast DNA, which is essential for chromosomal segregation and cell cycle progression, especially in eye development. The proteins belong to the metallo-dependent hydrolases superfamily and share a common TatD-type hydrolase domain.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR10060
Representative structure
8efg: Crystal structure of human TATDN1 bound to dAMP and two zinc ions