F
IPR050963

Sirohydrochlorin Cobaltochelatase/CbiX
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameSirohydro_Cobaltochel/CbiX
AI

Description

AI-generatedUnreviewed
The CbiX family proteins are involved in the anaerobic biosynthesis of cobalamin (vitamin B12) and the unique nickel-containing tetrapyrrole coenzyme F430. Members of the family catalyze the insertion of Co(2+) or Ni(2+) into sirohydrochlorin to yield cobalt-sirohydrochlorin or Ni-sirohydrochlorin, respectively. These steps are crucial for the production of cobalamin and coenzyme F430, the latter being the prosthetic group of methyl-coenzyme M reductase (MCR), essential for methanogenesis and anaerobic methane oxidation. Some subfamilies, such as the SirB subfamily, are involved in siroheme biosynthesis, catalyzing the chelation of iron into the siroheme precursor. The CbiX family displays a diversity of domain arrangements and may contain additional features such as an [Fe-S] cluster, which plays a regulatory role in iron, sulfur, and tetrapyrrole metabolism.

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