F
IPR050998

Forkhead box protein P
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameFOXP
AI

Description

AI-generatedUnreviewed
The FOXP family of transcription factors is characterized by a conserved fork-head DNA-binding domain and often contains a leucine-zipper motif for dimerization and transcriptional repression. Members of the family play critical roles in various biological processes, including immune system homeostasis, lung epithelium differentiation, neural development, and cardiovascular tissue formation. FOXP proteins can act as transcriptional repressors or activators, depending on their interaction partners. FOXP2 is notable for its involvement in speech and language development, while FOXP3 is essential for regulatory T-cell function and immune regulation. FOXP1 is involved in B-cell development, lung epithelium specification, and cardiac muscle cell proliferation. These proteins can interact with CTBP1 to repress transcription, influence synapse formation, and regulate the expression of genes involved in immune responses and cell fate determination.
Contributing Member Database Entry
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