F
IPR051034

Mitochondrial Enoyl-ACP Reductase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameMito_Enoyl-ACP_Reductase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The mitochondrial enoyl-[acyl-carrier-protein] reductase family is involved in the NADPH-dependent reduction of trans-2-enoyl thioesters as part of mitochondrial fatty acid synthesis type II. Members of this family utilize acyl carrier protein (ACP) as an acyl group carrier, although they can also accept CoA thioesters as substrates in vitro. The family plays a crucial role in fatty acid chain elongation within mitochondria, which is essential for respiration and the maintenance of the mitochondrial compartment. Some members display substrate specificity, showing a preference for medium-chain substrates and may contribute to lipoic acid biosynthesis, which is important for protein lipoylation and mitochondrial respiratory activity, particularly in certain cell types like Purkinje cells.

Cross References

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