F
IPR051084

Proton-coupled symporters
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameH+-coupled_symporters
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
This family of proteins is involved in the transport of various substrates across cellular membranes through a symport mechanism, where the transport of the substrate is coupled with the movement of protons into the cell. Members of this family function as osmosensors and osmoregulators, responding to osmotic shifts by importing osmolytes such as proline, glycine betaine, and other compatible solutes. Some proteins in this family are specific for the uptake of citrate, while others are more versatile and can transport a range of osmoprotectants including ectoine, pipecolic acid, and alpha-ketoglutarate. The activity of these transporters can be regulated by environmental factors such as osmotic stress, and some are inhibited by uncouplers like CCCP. Collectively, these proteins play a critical role in maintaining cellular homeostasis under varying environmental conditions.
Contributing Member Database Entry
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