F
IPR051117

T cell receptor gamma variable/constant region
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameTRG_var/const_region
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The T cell receptor gamma (TRG) family includes proteins involved in antigen recognition and the initiation of innate-like immune responses. TRG proteins are expressed on the surface of T cells, particularly gamma-delta T cells, which recognize self and foreign non-peptide antigens at epithelial boundaries. Antigen binding to TRG leads to phosphorylation of CD3 ITAMs, recruitment and activation of ZAP70, and subsequent signal transduction involving LCP2, LAT, and PLCG1. This cascade results in calcium mobilization, ERK activation, T cell proliferation, and differentiation. TRG diversity arises from somatic rearrangement of V, D, and J genes, with additional diversity from exonuclease trimming and random nucleotide additions during rearrangement. Some TRG members are non-functional due to altered recombination, splicing, or conserved amino acid changes.
Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.